SrasV1, Main, Exploration, bibRecord, 004E10

Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain

Identifieur interne : 004E10 ( Main/Exploration ); précédent : 004E09; suivant : 004E11

Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain

Source :

Vaccine [ 0264-410X ] ; 2005.

RBID : Pascal:06-0185934

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (analyse), Anticorps antiviraux (biosynthèse), Données de séquences moléculaires, Immunisation, Immunoglobuline G (analyse), Immunoglobuline G (biosynthèse), Immunoglobuline M (analyse), Immunoglobuline M (biosynthèse), Souris, Souris de lignée BALB C, Spécificité des anticorps, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Technique de Western, Test ELISA, Tests de neutralisation, Vaccins antiviraux (immunologie), Vaccins inactivés, Virus du SRAS (immunologie).
MESH :
- analyse : Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- biosynthèse : Anticorps antiviraux, Immunoglobuline G, Immunoglobuline M.
- immunologie : Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Animaux, Données de séquences moléculaires, Immunisation, Souris, Souris de lignée BALB C, Spécificité des anticorps, Technique de Western, Test ELISA, Tests de neutralisation, Vaccins inactivés, Virus syndrome respiratoire aigu sévère, Réponse immune, Souche inactivée, Souche vaccinale, Vaccin, Immunogénicité, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Animals, Antibodies, Viral (analysis), Antibodies, Viral (biosynthesis), Antibody Specificity, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Immune response, Immunization, Immunogenicity, Immunoglobulin G (analysis), Immunoglobulin G (biosynthesis), Immunoglobulin M (analysis), Immunoglobulin M (biosynthesis), Inactivated strain, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mouse, Neutralization Tests, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccine, Vaccine strain, Vaccines, Inactivated, Viral Vaccines (immunology).
MESH :
- chemical , analysis : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, Viral Vaccines.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Antibody Specificity, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Immunization, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Neutralization Tests, Vaccines, Inactivated.

Abstract

The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(OH)₃adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115646

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain</title>
<author><name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedicine Research and Development Center Jinan University</s1>
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<author><name sortKey="Lu, Jia Hai" sort="Lu, Jia Hai" uniqKey="Lu J" first="Jia-Hai" last="Lu">Jia-Hai Lu</name>
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<author><name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name>
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<author><name sortKey="Zheng, Huan Ying" sort="Zheng, Huan Ying" uniqKey="Zheng H" first="Huan-Ying" last="Zheng">Huan-Ying Zheng</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Center for Diseases Control and Prevention of Guangdong Province</s1>
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<author><name sortKey="Sheng Xiong" sort="Sheng Xiong" uniqKey="Sheng Xiong" last="Sheng Xiong">SHENG XIONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedicine Research and Development Center Jinan University</s1>
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<author><name sortKey="Zhang, Mei Ying" sort="Zhang, Mei Ying" uniqKey="Zhang M" first="Mei-Ying" last="Zhang">Mei-Ying Zhang</name>
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<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Xin Jian" sort="Liu, Xin Jian" uniqKey="Liu X" first="Xin-Jian" last="Liu">Xin-Jian Liu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedicine Research and Development Center Jinan University</s1>
<s2>Guangzhou 510632</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jiu Xiang" sort="Li, Jiu Xiang" uniqKey="Li J" first="Jiu-Xiang" last="Li">Jiu-Xiang Li</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedicine Research and Development Center Jinan University</s1>
<s2>Guangzhou 510632</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>République populaire de Chine</country>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Center for Diseases Control and Prevention of Guangdong Province</s1>
<s2>Guangzhou 510300</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Xin Ge" sort="Yan, Xin Ge" uniqKey="Yan X" first="Xin-Ge" last="Yan">Xin-Ge Yan</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Center for Diseases Control and Prevention of Guangdong Province</s1>
<s2>Guangzhou 510300</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Shu Yuan" sort="Qi, Shu Yuan" uniqKey="Qi S" first="Shu-Yuan" last="Qi">Shu-Yuan Qi</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>South China Institute of Botany, Graduate School of the Chinese Academy of Sciences</s1>
<s2>Guangzhou 510650</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhiyong Cui" sort="Zhiyong Cui" uniqKey="Zhiyong Cui" last="Zhiyong Cui">ZHIYONG CUI</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Program in Molecular Medicine, University of Massachusetts Medical School</s1>
<s2>Worcester, MA 01605</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Biliang Zhang" sort="Biliang Zhang" uniqKey="Biliang Zhang" last="Biliang Zhang">BILIANG ZHANG</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Program in Molecular Medicine, University of Massachusetts Medical School</s1>
<s2>Worcester, MA 01605</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou International Business Incubator, Guangzhou Science Park</s1>
<s2>Guangzhou 510663</s2>
<s3>CHN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Vaccine</title>
<title level="j" type="abbreviated">Vaccine</title>
<idno type="ISSN">0264-410X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (analysis)</term>
<term>Antibodies, Viral (biosynthesis)</term>
<term>Antibody Specificity</term>
<term>Blotting, Western</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Immune response</term>
<term>Immunization</term>
<term>Immunogenicity</term>
<term>Immunoglobulin G (analysis)</term>
<term>Immunoglobulin G (biosynthesis)</term>
<term>Immunoglobulin M (analysis)</term>
<term>Immunoglobulin M (biosynthesis)</term>
<term>Inactivated strain</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Molecular Sequence Data</term>
<term>Mouse</term>
<term>Neutralization Tests</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Vaccine</term>
<term>Vaccine strain</term>
<term>Vaccines, Inactivated</term>
<term>Viral Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Anticorps antiviraux (biosynthèse)</term>
<term>Données de séquences moléculaires</term>
<term>Immunisation</term>
<term>Immunoglobuline G (analyse)</term>
<term>Immunoglobuline G (biosynthèse)</term>
<term>Immunoglobuline M (analyse)</term>
<term>Immunoglobuline M (biosynthèse)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité des anticorps</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Technique de Western</term>
<term>Test ELISA</term>
<term>Tests de neutralisation</term>
<term>Vaccins antiviraux (immunologie)</term>
<term>Vaccins inactivés</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
<term>Immunoglobulin M</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin G</term>
<term>Immunoglobulin M</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Immunoglobuline G</term>
<term>Immunoglobuline M</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Immunoglobuline G</term>
<term>Immunoglobuline M</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Vaccins antiviraux</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Antibody Specificity</term>
<term>Blotting, Western</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Immunization</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Vaccines, Inactivated</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Immunisation</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité des anticorps</term>
<term>Technique de Western</term>
<term>Test ELISA</term>
<term>Tests de neutralisation</term>
<term>Vaccins inactivés</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Réponse immune</term>
<term>Souche inactivée</term>
<term>Souche vaccinale</term>
<term>Vaccin</term>
<term>Immunogénicité</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The immunogenicity of a candidate-inactivated vaccine prepared from SARS-CoV F69 strain was evaluated in Balb/c mice. Potent humoral immune responses were induced under the elicitation of three times of immunizations at 2-week intervals with this vaccine, combined with three types of adjuvants (Freund's adjuvant, Al(OH)<sub>3</sub>
adjuvant and CpG adjuvant). Titers of specific IgG antibodies in three test groups all peaked in the sixth week after first vaccination, but significant differences existed in the kinetics of specific IgG antibody levels. The strong neutralizing capacity exhibited in micro-cytopathic effect neutralization tests indicated the specific antibodies are protective. Western blot assay further demonstrated the specificity of the induced serum antibodies.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Guangdong</li>
<li>Massachusetts</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name>
</region>
<name sortKey="Biliang Zhang" sort="Biliang Zhang" uniqKey="Biliang Zhang" last="Biliang Zhang">BILIANG ZHANG</name>
<name sortKey="Li, Jiu Xiang" sort="Li, Jiu Xiang" uniqKey="Li J" first="Jiu-Xiang" last="Li">Jiu-Xiang Li</name>
<name sortKey="Liu, Xin Jian" sort="Liu, Xin Jian" uniqKey="Liu X" first="Xin-Jian" last="Liu">Xin-Jian Liu</name>
<name sortKey="Lu, Jia Hai" sort="Lu, Jia Hai" uniqKey="Lu J" first="Jia-Hai" last="Lu">Jia-Hai Lu</name>
<name sortKey="Qi, Shu Yuan" sort="Qi, Shu Yuan" uniqKey="Qi S" first="Shu-Yuan" last="Qi">Shu-Yuan Qi</name>
<name sortKey="Sheng Xiong" sort="Sheng Xiong" uniqKey="Sheng Xiong" last="Sheng Xiong">SHENG XIONG</name>
<name sortKey="Wan, Zhuo Yue" sort="Wan, Zhuo Yue" uniqKey="Wan Z" first="Zhuo-Yue" last="Wan">Zhuo-Yue Wan</name>
<name sortKey="Wang, Yi Fei" sort="Wang, Yi Fei" uniqKey="Wang Y" first="Yi-Fei" last="Wang">Yi-Fei Wang</name>
<name sortKey="Yan, Xin Ge" sort="Yan, Xin Ge" uniqKey="Yan X" first="Xin-Ge" last="Yan">Xin-Ge Yan</name>
<name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name>
<name sortKey="Zhang, Chuan Hai" sort="Zhang, Chuan Hai" uniqKey="Zhang C" first="Chuan-Hai" last="Zhang">Chuan-Hai Zhang</name>
<name sortKey="Zhang, Mei Ying" sort="Zhang, Mei Ying" uniqKey="Zhang M" first="Mei-Ying" last="Zhang">Mei-Ying Zhang</name>
<name sortKey="Zheng, Huan Ying" sort="Zheng, Huan Ying" uniqKey="Zheng H" first="Huan-Ying" last="Zheng">Huan-Ying Zheng</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Zhiyong Cui" sort="Zhiyong Cui" uniqKey="Zhiyong Cui" last="Zhiyong Cui">ZHIYONG CUI</name>
</region>
<name sortKey="Biliang Zhang" sort="Biliang Zhang" uniqKey="Biliang Zhang" last="Biliang Zhang">BILIANG ZHANG</name>
</country>
</tree>
</affiliations>
</record>

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Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain

Immune responses in Balb/c mice induced by a candidate SARS-CoV inactivated vaccine prepared from F69 strain

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